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. 1983 Apr;4(1):35-7.
doi: 10.1007/BF02043435.

Variations in the 5-hydroxy-indoleacetic acid concentration in the cerebrospinal fluid during the sleep-wake cycle in man

R Raffaele, A Reggio, R Tropea, G Pennisi, A Falsaperla, F Nicoletti

Variations in the 5-hydroxy-indoleacetic acid concentration in the cerebrospinal fluid during the sleep-wake cycle in man

R Raffaele et al. Ital J Neurol Sci. 1983 Apr.

Abstract

A variation in the ventricular fluid 5-HIAA concentration has been observed during the phases of the sleep-wake cycle in man. This variation affects the NREM phase, during which 5-HIAA increases markedly, rather than the waking state and the REM phase. The results are discussed in relation to the possible relevance of serotonin to the sleep mechanism.

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