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Comparative Study
. 1983 Jul 1;158(1):252-7.
doi: 10.1084/jem.158.1.252.

Metabolism of formycin B by Leishmania amastigotes in vitro. Comparative metabolism in infected and uninfected human macrophages

J D Berman, P Rainey, D V Santi
Comparative Study

Metabolism of formycin B by Leishmania amastigotes in vitro. Comparative metabolism in infected and uninfected human macrophages

J D Berman et al. J Exp Med. .

Abstract

Formycin B is metabolized by cutaneous Leishmania amastigotes within cultured human macrophages to give formycin B 5'-monophosphate and formycin A 5'-mono-, di-, and triphosphates. Formycin A is also incorporated into RNA. The activity of formycin B against amastigotes was correlated with the levels of formycin A metabolites formed in the parasites. Uninfected macrophages also convert formycin B into the same products, but the levels are markedly lower than those seen in infected macrophages. The results suggest that a sufficient therapeutic index exists to warrant consideration of formycin B as an anti-leishmanial drug in humans.

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References

    1. J Antibiot (Tokyo). 1967 Nov;20(6):308-16 - PubMed
    1. Clin Chem. 1975 Aug;21(9):1245-52 - PubMed
    1. Infect Immun. 1979 Oct;26(1):375-9 - PubMed
    1. J Infect Dis. 1980 Jul;142(1):83-6 - PubMed
    1. Biochem Biophys Res Commun. 1981 Jun 16;100(3):1377-83 - PubMed

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