Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1983 Apr;13(2-3):144-8.
doi: 10.1007/BF01967319.

Calcium antagonists and histamine secretion from rat peritoneal mast cells

M Ennis, P W Ind, F L Pearce, C T Dollery

Calcium antagonists and histamine secretion from rat peritoneal mast cells

M Ennis et al. Agents Actions. 1983 Apr.

Abstract

The calcium antagonists verapamil and nifedipine inhibited histamine release induced from rat peritoneal mast cells by a number of secretory stimuli. However, the concentrations required were much higher than those active in smooth muscle preparations. The inhibition was unaffected by elevated levels of external calcium and the drugs prevented release in the absence of added calcium. The novel calcium antagonist, PY 108-068, had no effect on histamine secretion from mast cells. These results suggest that calcium channels in the mastocyte may differ from those in smooth muscle and that at concentrations required to inhibit secretion, verapamil and nifedipine may have non-specific stabilizing effects on the mast cell membrane.

PubMed Disclaimer

References

    1. Thorax. 1981 Oct;36(10):726-30 - PubMed
    1. Int Arch Allergy Appl Immunol. 1980;62(4):467-71 - PubMed
    1. Br Med J (Clin Res Ed). 1981 Mar 21;282(6268):932-3 - PubMed
    1. Agents Actions. 1980 Apr;10(1 Pt 2):124-31 - PubMed
    1. Prog Med Chem. 1982;19:59-109 - PubMed

Publication types