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Comparative Study
. 1983 Jun;27(3):203-5.
doi: 10.1111/j.1399-6576.1983.tb01935.x.

Intradermal histamine release by 3 muscle relaxants

E N Robertson, L H Booij, R J Fragen, J F Crul
Comparative Study

Intradermal histamine release by 3 muscle relaxants

E N Robertson et al. Acta Anaesthesiol Scand. 1983 Jun.

Abstract

The induration and redness caused by intradermal injections of equipotent doses of atracurium, vecuronium and d-tubocurarine were measured in six healthy, male volunteers. Atracurium and d-tubocurarine were almost indistinguishable in their reactions. Vecuronium caused a significantly smaller response than both atracurium and d-tubocurarine. We therefore suggest that of these three drugs, vecuronium may cause the least histamine release and is, perhaps, the drug of choice in patients with a history of asthma or allergy.

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