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. 1983 Sep 15;39(9):1018-20.
doi: 10.1007/BF01989781.

Localization of substance P-immunoreactive nerve fibers in the human digital skin

C J Dalsgaard, C E Jonsson, T Hökfelt, A C Cuello

Localization of substance P-immunoreactive nerve fibers in the human digital skin

C J Dalsgaard et al. Experientia. .

Abstract

Substance P-immunoreactive nerve endings were localized in human digital skin by the use of indirect immunohistochemical technique. It was found that substance P-like immunoreactivity was present in free nerve endings in the dermal papillae and in the epidermis. Some Meissner's corpuscles also contained substance P positive nerve endings. Furthermore, substance P-immunoreactive nerves were localized in close connection to sweat gland ducts and blood vessels. The functional significance of these findings was discussed with regard to pain mediation and inflammatory response.

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References

    1. Gen Cytochem Methods. 1958;1:399-422 - PubMed
    1. Nat New Biol. 1971 Jul 21;232(29):86-7 - PubMed
    1. Science. 1975 Nov 28;190(4217):889-90 - PubMed
    1. J Physiol. 1931 Jun 6;72(1):74-87 - PubMed
    1. Proc Natl Acad Sci U S A. 1982 Feb;79(4):1303-7 - PubMed

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