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. 1983 Aug 15;214(2):637-40.
doi: 10.1042/bj2140637.

The effect of tri-iodothyronine administration on protein synthesis in the diabetic rat

J G Brown, J van Bueren, D J Millward

The effect of tri-iodothyronine administration on protein synthesis in the diabetic rat

J G Brown et al. Biochem J. .

Abstract

In young male rats diabetes caused decreases in circulating free tri-iodothyronine and RNA concentration in liver and muscle, and in the rate of protein synthesis per unit of RNA (RNA activity) in muscle. Tri-iodothyronine treatment significantly increased RNA concentrations, but not RNA activity, in these tissues. Thus: (1) impaired thyroid status is a component of the diabetic condition; (2) tri-iodothyronine cannot stimulate the translational phase of protein synthesis in the diabetic rat.

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