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. 1983;2(4):555-9.
doi: 10.1002/j.1460-2075.1983.tb01462.x.

The molecular basis of the antigenic variation of foot-and-mouth disease virus

E Beck, G Feil, K Strohmaier

The molecular basis of the antigenic variation of foot-and-mouth disease virus

E Beck et al. EMBO J. 1983.

Abstract

We have cloned and sequenced the viral protein (VP1)-coding regions of two foot-and-mouth disease virus (FMDV) serotypes (C1 and A5). Comparison of the derived amino acid sequences with the known VP1 sequence of FMDV O1K and the two FMDV A subtypes A10 and A12 shows two highly variable regions in the protein, at positions 40-60 and 130-160, as possible antigenic sites. In both variable regions, several sites could be detected where all three sequences of the A subtypes are identical but the three types A, C and O differ from each other. The second variable region overlaps with a major immunogenic determinant of the virus.

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