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. 1983 Oct;25(4):322-4.
doi: 10.1007/BF00253194.

Circulating IgG antibody to protamine in patients treated with protamine-insulins

A B Kurtz, R S Gray, S Markanday, J D Nabarro

Circulating IgG antibody to protamine in patients treated with protamine-insulins

A B Kurtz et al. Diabetologia. 1983 Oct.

Abstract

Sera from patients with different types of protamine-insulin were assayed for IgG antibody to protamine. A high prevalence of circulating antibody was found in patients treated with either bovine isophane insulin (26 out of 28 patients; 26 of whom also had antibodies to insulin), or bovine protamine zinc insulin (27 out of 30 patients; all 30 had antibodies to insulin). In sera from 24 patients treated with highly purified porcine isophane insulin, protamine antibody was detected in nine; circulating insulin-antibody was detected in 12 patients, eight of whom had protamine-antibody; in the 12 patients with no detectable antibody to insulin, antibody to protamine was detected in only one (x2 = 8.7, p less than 0.01). This relationship between insulin and protamine antigenicity is of interest as it suggests that the protamine-insulin complex is itself immunogenic.

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