doi: 10.1016/0076-6879(83)99073-0.
Characterization of the Abelson murine leukemia virus-encoded tyrosine-specific protein kinase
- PMID: 6196601
- DOI: 10.1016/0076-6879(83)99073-0
Item in Clipboard
Characterization of the Abelson murine leukemia virus-encoded tyrosine-specific protein kinase
Methods Enzymol.
1983.
Abstract
There is sufficient evidence that the A-MuL V protein is a tyrosine-specific protein kinase. There are methods for detecting this kinase activity and this kinase has been expressed in E. coli. Because the information coding for the tyrosine-specific protein kinase is present in normal mouse cells, such an enzyme must have a normal physiologic function. The elucidation of this physiologic function and the understanding of the role of this enzyme activity in neoplastic transformation is the challenge of the future.
Similar articles
-
Evidence that the Abelson virus protein functions in vivo as a protein kinase that phosphorylates tyrosine.Proc Natl Acad Sci U S A. 1981 Mar;78(3):1552-6. doi: 10.1073/pnas.78.3.1552. Proc Natl Acad Sci U S A. 1981. PMID: 6262813 Free PMC article.
-
Purification and characterization of a protein-tyrosine kinase encoded by the Abelson murine leukemia virus.J Biol Chem. 1985 Jul 5;260(13):8070-7. J Biol Chem. 1985. PMID: 2989275
-
Temperature-sensitive mutants of Abelson murine leukemia virus deficient in protein tyrosine kinase activity.J Virol. 1990 Sep;64(9):4242-51. doi: 10.1128/JVI.64.9.4242-4251.1990. J Virol. 1990. PMID: 1696637 Free PMC article.
-
Abelson-transformed fibroblasts contain nuclear phosphotyrosyl-proteins which preferentially bind to murine DNA.Nature. 1987 Feb 5-11;325(6104):552-4. doi: 10.1038/325552a0. Nature. 1987. PMID: 2433597
-
Molecular and cellular biology of Abelson virus transformation.Curr Top Microbiol Immunol. 1983;103:127-46. doi: 10.1007/978-3-642-68943-7_6. Curr Top Microbiol Immunol. 1983. PMID: 6303708 Review. No abstract available.
Cited by
-
Insertional mutagenesis of the Abelson murine leukemia virus genome: identification of mutants with altered kinase activity and defective transformation ability.J Virol. 1988 Mar;62(3):978-86. doi: 10.1128/JVI.62.3.978-986.1988. J Virol. 1988. PMID: 2828693 Free PMC article.