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Case Reports
. 1984 Jan;48(1):27-31.
doi: 10.1007/BF00320714.

Release of platelets into the circulation induced by gamma globulin treatment in a case of idiopathic thrombocytopenic purpura

K G Schmidt, J W Rasmussen, H Diederichsen, M Ulrich
Case Reports

Release of platelets into the circulation induced by gamma globulin treatment in a case of idiopathic thrombocytopenic purpura

K G Schmidt et al. Blut. 1984 Jan.

Abstract

The kinetics and distribution in vivo of 111In-labelled platelets prior to and during intravenous high-dose gamma globulin therapy in a 3-months-old child with idiopathic thrombocytopenic purpura were evaluated. Concomitantly with a prompt increase in platelet concentration we found evidence for release of platelets into the circulation, presumably to a large extent originating from the spleen and liver. Our results support the concept that, in response to high-dose gamma globulin therapy, platelets are not only forced to remain in but are also released into the circulation, presumably as a result of mobilization of platelets adhering to cells of the monocyte-macrophage system.

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