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. 1983 Jun;79(2):330-3.
doi: 10.1111/j.1476-5381.1983.tb11004.x.

Substance P inhibits the M-current in bullfrog sympathetic neurones

P R Adams, D A Brown, S W Jones

Substance P inhibits the M-current in bullfrog sympathetic neurones

P R Adams et al. Br J Pharmacol. 1983 Jun.

Abstract

Substance P (SP, 2.5-10 microM) was applied by rapid bath perfusion to bullfrog lumbar sympathetic neurones in vitro, voltage-clamped through a single micro-electrode. In unclamped cells, SP produced a depolarization accompanied by an increase in apparent input resistance. Under voltage-clamp a voltage-dependent inward current was induced by SP, during which the time-dependent relaxations induced by square voltage commands were inhibited. It is concluded that SP inhibits the M-current (IM), a species of voltage-dependent K+-current, and that IM-inhibition was the primary cause of the inward current and membrane depolarization in the cells tested.

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References

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