doi: 10.1016/0014-5793(83)80033-7.
Galanin - a novel biologically active peptide from porcine intestine
- PMID: 6197320
- DOI: 10.1016/0014-5793(83)80033-7
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Galanin - a novel biologically active peptide from porcine intestine
FEBS Lett.
.
Free article
Abstract
The isolation of a novel biologically active peptide, designated galanin, is described. The peptide was discovered by the detection of its C-terminal amide structure in porcine intestinal extract using a chemical method. It was found that galanin consists of 29 amino acids and the complete amino acid sequence is: Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-His-Ala-Ile-Asp-Asn-His -Arg-Ser -Phe-His-Asp-Lys-Tyr-Gly-Leu-Ala-NH2. Galanin was found to contract smooth muscle preparations from the rat and to cause a mild and sustained hyperglycemia in dog.
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