[Tissue concentrations of mezlocillin in prostate adenomas following intravenous bolus injections and continuous infusions]

Abstract

In a total of 23 patients undergoing transurethral resection or suprapubic operation of benign hypertrophy of prostate perioperative antibiotic prophylaxis was started with 5 g of mezlocillin in each patient. In 5 patients (group I) the antibiotic was slowly (3 min) injected i.v. In 5 patients (group II) mezlocillin was administered as i.v. bolus injection of 1 g followed by i.v. infusion of 4 g during one hour. In 7 patients (group III) and in 6 patients (group IV) mezlocillin was administered as i.v. bolus injection of 1 g followed by i.v. infusion of 4 g during 4 hours. In the patients of group I-III a transurethral resection and in the patients of group IV a suprapubic prostatectomy was performed. Serum concentrations of mezlocillin were determined in intervals up to 4 hours after start of administration. The prostatic tissue concentrations were determined in both prostatic lobes in group I and group II 60 and 90 min and in group III and IV 4 hours after start of administration. In group V several tissue samples of the prostatic adenoma were obtained. The serum concentrations showed considerable interindividual variations, because the dose of antibiotic was the same in each patient and not adapted to the body weight. In group I the mean prostatic tissue concentrations at 60 min and 90 min after start of administration were 76 micrograms/g and 31 micrograms/g, respectively, in group II the mean prostatic tissue concentrations at 60 min and 90 min were 78 micrograms/g and 24 micrograms/g, respectively. In group III the mean tissue concentration at the end of the 4-hours infusion was 29 micrograms/g. In 2 patients of this group the concentrations of the 2 prostatic lobes differed considerably. In group IV measurable tissue concentrations of mezlocillin were found in 2 patients only. Considerable variations were found within the prostatic adenoma ranging from "non detectable" to approximately half of the serum concentration.(ABSTRACT TRUNCATED AT 250 WORDS)