Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1984 Jan;49(1):248-52.
doi: 10.1128/JVI.49.1.248-252.1984.

Antigenic characterization of influenza A virus matrix protein with monoclonal antibodies

K L van Wyke, J W Yewdell, L J Reck, B R Murphy

Antigenic characterization of influenza A virus matrix protein with monoclonal antibodies

K L van Wyke et al. J Virol. 1984 Jan.

Abstract

Monoclonal antibodies were used to study antigenic variation in three distinct epitopes on the matrix protein of influenza A viruses. We found that two of these epitopes underwent antigenic variation, but in a very limited number of virus strains. A third epitope appeared to be an invariant type-specific determinant for influenza A viruses. Competitive antibody binding assays and Western blot analysis of proteolytically digested matrix protein indicated that at least two of the three epitopes are located in nonoverlapping domains on the matrix protein molecule.

PubMed Disclaimer

References

    1. Biochim Biophys Acta. 1974 Apr 8;344(1):51-94 - PubMed
    1. J Exp Med. 1960 Nov 1;112:921-44 - PubMed
    1. J Exp Med. 1976 Oct 1;144(4):985-95 - PubMed
    1. Eur J Immunol. 1976 Jul;6(7):511-9 - PubMed
    1. J Biol Chem. 1977 Feb 10;252(3):1102-6 - PubMed

LinkOut - more resources