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. 1983 Sep;39(1):30-9.
doi: 10.1016/s0163-1047(83)90586-1.

Substance p reversal of electroconvulsive shock and cycloheximide-induced retrograde amnesia

K Schlesinger, D U Lipsitz, P L Peck, M A Pelleymounter, J M Stewart, T N Chase

Substance p reversal of electroconvulsive shock and cycloheximide-induced retrograde amnesia

K Schlesinger et al. Behav Neural Biol. 1983 Sep.

Abstract

Subcutaneous post-trial administration of the neuropeptide substance P was found to reverse the amnestic effects of both electroconvulsive shock and cycloheximide. Substance P was observed to reverse the amnestic effects of cycloheximide in both C57B1/6J and heterogeneous strain (HS) mice. Substance P was found to reverse the amnestic effects of electroconvulsive seizures in C57B1/6J animals. Peripheral injections of substance P were also found to facilitate the retention of a single-trial passive avoidance habit in animals of both genotypes, provided a weak footshock was used during training.

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