doi: 10.1126/science.6198721.
Antibody to hepatitis B virus induced by injecting antibodies to the idiotype
- PMID: 6198721
- DOI: 10.1126/science.6198721
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Antibody to hepatitis B virus induced by injecting antibodies to the idiotype
Science.
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Abstract
Anti-idiotype reagents that recognize a common idiotype associated with antibody to hepatitis B surface antigen (anti-HBs) were used to induce anti-HBs in mice. The anti-idiotype-induced anti-HBs was found to recognize the group-specific a determinant of hepatitis B surface antigen and to express an interspecies idiotype. These findings suggest that anti-idiotypes may be useful as vaccines or vaccine primers.
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