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. 1984 Mar 2;223(4639):930-1.
doi: 10.1126/science.6198721.

Antibody to hepatitis B virus induced by injecting antibodies to the idiotype

R C Kennedy, J L Melnick, G R Dreesman

Antibody to hepatitis B virus induced by injecting antibodies to the idiotype

R C Kennedy et al. Science. .

Abstract

Anti-idiotype reagents that recognize a common idiotype associated with antibody to hepatitis B surface antigen (anti-HBs) were used to induce anti-HBs in mice. The anti-idiotype-induced anti-HBs was found to recognize the group-specific a determinant of hepatitis B surface antigen and to express an interspecies idiotype. These findings suggest that anti-idiotypes may be useful as vaccines or vaccine primers.

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