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. 1984 Feb 27;294(1):174-7.
doi: 10.1016/0006-8993(84)91326-x.

Behavioral and biochemical stereoselectivity of sigma opiate/PCP receptors

S R Zukin, K T Brady, B L Slifer, R L Balster

Behavioral and biochemical stereoselectivity of sigma opiate/PCP receptors

S R Zukin et al. Brain Res. .

Abstract

The relative potencies of the stereoisomers of ketamine, N-allylnormetazocine and cyclazocine were determined at mu opiate and sigma opiate/phencyclidine (PCP) receptors in vitro in rat brain homogenates, as well as in a discriminative stimulus behavioral paradigm in rats trained to discriminate PCP from saline. In all cases the in vivo and in vitro data were in agreement. The (+)-isomers of N-allylnormetazocine and cyclazocine are highly specific sigma opiate/PCP ligands.

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