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. 1976 Oct;117(4):1132-8.

Coexistence of helper and suppressor activities in carrier-primed spleen cells

E L Chan, C Henry
  • PMID: 61991

Coexistence of helper and suppressor activities in carrier-primed spleen cells

E L Chan et al. J Immunol. 1976 Oct.

Abstract

Both helper and suppressor activities for an in vitro IgG anti-hapten (Lac) response to Lac-HRBC were demonstrated in the same population of carrier (HRBC)-primed spleen cells. The relative radiosensitivity of suppressor activity permitted the selective removal of suppression and the demonstration of help. Both activities appear to be T cell-dependent and antigen-specific. Dilution analysis showed that help and suppression are mediated by distinct populations of cells.

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