Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1978 Feb;5(2):181-5.
doi: 10.1111/j.1365-2125.1978.tb01621.x.

The effect of vitamin supplementation upon antipyrine metabolism in the elderly

D J Smithard, M J Langman

The effect of vitamin supplementation upon antipyrine metabolism in the elderly

D J Smithard et al. Br J Clin Pharmacol. 1978 Feb.

Abstract

1 Antipyrine plasma half-life and clearance rates were studied in 19 elderly patients shortly after admission to a geriatric ward and again 2 weeks after a course of dietary supplementation with Vitamins A, B complex, C and D. 2 Antipyrine half-life fell and clearance increased in the nine who had sub-clinical evidence of ascorbic acid deficiency. No correlation was found with other indices of nutritional status. 3 Vitamin supplementation in elderly people with no demonstrable deficiencies did not alter the metabolism of antipyrine.

PubMed Disclaimer

References

    1. Clin Sci. 1961 Oct;21:157-62 - PubMed
    1. J Pharmacol Exp Ther. 1954 Jun;111(2):176-81 - PubMed
    1. Eur J Clin Pharmacol. 1975;8(1):55-62 - PubMed
    1. Gut. 1976 Aug;17(8):571-5 - PubMed
    1. Biochem Pharmacol. 1974 Nov 15;23(22):3121-8 - PubMed

LinkOut - more resources