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Case Reports
. 1983 Dec;29(15):1779-82.

[A case of advanced testicular seminoma--chemotherapy and serum marker]

[Article in Japanese]
K Nakamura, M Hagiwara, A Aikawa, N Deguchi, H Tazaki, E Takeshita, S Ito
  • PMID: 6199531
Case Reports

[A case of advanced testicular seminoma--chemotherapy and serum marker]

[Article in Japanese]
K Nakamura et al. Gan No Rinsho. 1983 Dec.

Abstract

A 52 year-old male with advanced testicular seminoma (stage II N4) underwent right radical orchiectomy, followed by chemotherapy with vinblastine, bleomycin and cis-platinum. This resulted a partial response and he was well for 24 months after the operation. Serial monitoring of serum HCG and HCG-beta has been done, using three kinds of double antibody radioimmunoassays. A substance with immunological similarity to free HCG-beta was detected in sera and tumor extract. The serum level of this substance was reduced in parallel with the cytoreduction of metastasis by chemotherapy. A rational therapeutic approach to advanced seminoma and its serum marker are discussed briefly.

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