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Comparative Study
. 1983;53(6):521-8.

[Macrophage adherence inhibition test (MAI) in Wistar rats bearing Jensen tumors. I. MAI after incubation with tumor-associated antigens]

[Article in German]
B Neumeister, K Hambsch, H Storch
  • PMID: 6200084
Comparative Study

[Macrophage adherence inhibition test (MAI) in Wistar rats bearing Jensen tumors. I. MAI after incubation with tumor-associated antigens]

[Article in German]
B Neumeister et al. Arch Geschwulstforsch. 1983.

Abstract

In the present report investigations for cellular sensitization against Jensen-sarcoma of the white rat are performed. Macrophage-Adherence-Inhibition-Test according to Halliday and Miller in a modification according to Schimke was the applied test. A significant adherence-inhibition of peritoneal cells of tumor-bearing rats was found in comparison to control animals with a plateau on day 12 after transplantation and a praemortal eclipse phenomenon from day 19 after inoculation with tumor cells. The concentration of immune complexes shows the same manner, but was especially high in animals with small or not-taken tumors, whereas MAI-index was similar to that of the control group. Antibody production against the tumor could not be detected with Ouchterlony-precipitation. Non-specific immunotherapy with DNCB and BCG as well as therapy with soluble tumorantigen in KFA and insoluble polymerized extracts in 2 TU PPD were unsuccessful to prevent the development of tumors in the model.

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