doi: 10.1016/0006-291x(84)91612-7.
Biochemical correlates of phenotypic reversion in interferon-treated mouse cells transformed by a human oncogene
- PMID: 6200112
- DOI: 10.1016/0006-291x(84)91612-7
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Biochemical correlates of phenotypic reversion in interferon-treated mouse cells transformed by a human oncogene
Biochem Biophys Res Commun.
.
Abstract
Mouse interferon (IFN) induced a phenotypic reversion in RS 485, a clonal line of NIH 3T3 oncogenically transformed by a human c-Ha-rasl gene activated by Ha-MuSV long terminal repeats (LTRs). Transfected c-Ha-ras DNA, unchanged in quantity and distribution, as compared to the parental RS 485 transformed cells, was still present in these revertants; however, there was a significant reduction in the amount of c-Ha-ras specific mRNA and of c-Ha-ras specified p21 protein.
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