doi: 10.1084/jem.144.4.1134.
Cell-mediated lympholysis to H-2-matched target cells modified with a series of nitrophenyl compounds
- PMID: 62013
- PMCID: PMC2190423
- DOI: 10.1084/jem.144.4.1134
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Cell-mediated lympholysis to H-2-matched target cells modified with a series of nitrophenyl compounds
J Exp Med.
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Abstract
The specificity of C57BL/10 cytotoxic effector cells generated by in vitro sensitization with autologous spleen cells modified with a series of related nitrophenyl compounds was investigated. The failure of trinitrophenyl (TNP)-sensitized effector cells to lyse TNP-beta-alanylglycylglycyl(AGG)-modified target cells is presented as evidence contradicting the intimacy or dual receptor model or T-cell recognition in its simplest form. Data are also shown indicating that sensitization with N-(3-nitro-4-hydroxy-5-iodophenylacetyl)-AGG-modified stimulating cells generates noncross-reacting clones of cytotoxic effector cells.
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