Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1976 Oct 1;144(4):1134-40.
doi: 10.1084/jem.144.4.1134.

Cell-mediated lympholysis to H-2-matched target cells modified with a series of nitrophenyl compounds

T G Rehn, J K Inman, G M Shearer

Cell-mediated lympholysis to H-2-matched target cells modified with a series of nitrophenyl compounds

T G Rehn et al. J Exp Med. .

Abstract

The specificity of C57BL/10 cytotoxic effector cells generated by in vitro sensitization with autologous spleen cells modified with a series of related nitrophenyl compounds was investigated. The failure of trinitrophenyl (TNP)-sensitized effector cells to lyse TNP-beta-alanylglycylglycyl(AGG)-modified target cells is presented as evidence contradicting the intimacy or dual receptor model or T-cell recognition in its simplest form. Data are also shown indicating that sensitization with N-(3-nitro-4-hydroxy-5-iodophenylacetyl)-AGG-modified stimulating cells generates noncross-reacting clones of cytotoxic effector cells.

PubMed Disclaimer

References

    1. J Exp Med. 1976 Jan 1;143(1):211-7 - PubMed
    1. Eur J Immunol. 1975 Feb;5(2):122-7 - PubMed
    1. J Exp Med. 1972 Jun 1;135(6):1228-46 - PubMed
    1. Nature. 1974 Apr 19;248(5450):701-2 - PubMed
    1. Eur J Immunol. 1974 Aug;4(8):527-33 - PubMed