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. 1984 Apr;4(4):809-12.
doi: 10.1128/mcb.4.4.809-812.1984.

Spontaneous and 5-azacytidine-induced reexpression of ornithine carbamoyl transferase in hepatoma cells

A Delers, J Szpirer, C Szpirer, D Saggioro

Spontaneous and 5-azacytidine-induced reexpression of ornithine carbamoyl transferase in hepatoma cells

A Delers et al. Mol Cell Biol. 1984 Apr.

Abstract

Rat hepatoma cells that do not synthesize the hepatic enzyme ornithine carbamoyl transferase spontaneously give rise to producing cells at a low frequency. Reexpression of this differentiation trait is strongly increased by 5-azacytidine treatment, suggesting that hypermethylation plays a critical role in the impaired expression of the ornithine carbamoyl transferase gene in hepatoma cells.

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