Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1984 May;81(9):2912-6.
doi: 10.1073/pnas.81.9.2912.

The structure of bovine brain myelin proteolipid and its organization in myelin

R A Laursen, M Samiullah, M B Lees

The structure of bovine brain myelin proteolipid and its organization in myelin

R A Laursen et al. Proc Natl Acad Sci U S A. 1984 May.

Abstract

A model, based on amino acid sequence data, is proposed for the organization of the myelin proteolipid in myelin membrane. The model has three distinctive features: three trans-membrane segments that traverse the lipid bilayer, two cis-membrane domains that enter and exit the same side of the membrane, and a highly charged segment resembling myelin basic protein on the cytoplasmic side of the membrane. It is proposed that the cis-membrane domain(s) can promote the formation and stabilization of the multilamellar myelin structure by hydrophobic interaction with the apposite bilayer across the extracellular space.

PubMed Disclaimer

References

    1. J Neurochem. 1969 Jun;16(3):1025-32 - PubMed
    1. Nature. 1961 May 20;190:666-70 - PubMed
    1. Biochim Biophys Acta. 1978 Apr 10;515(1):1-21 - PubMed
    1. Nature. 1978 Apr 13;272(5654):586-90 - PubMed
    1. J Neurochem. 1978 May;30(5):983-90 - PubMed

Publication types

LinkOut - more resources