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. 1984 May 7;170(1):64-8.
doi: 10.1016/0014-5793(84)81369-1.

Synergistic effect of A23187 and a phorbol ester on amylase secretion from rabbit pancreatic acini

J J de Pont, A M Fleuren-Jakobs
Free article

Synergistic effect of A23187 and a phorbol ester on amylase secretion from rabbit pancreatic acini

J J de Pont et al. FEBS Lett. .
Free article

Abstract

The combination of the ionophore A23187 and the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA) stimulates amylase secretion from rabbit pancreatic acini up to a level equal to, or slightly higher than when carbachol is used as stimulant. Each of the two compounds alone gives only a minor stimulation. This synergistic effect of A23187 and TPA supports a role of protein kinase C in pancreatic enzyme secretion.

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