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. 1984 Jun;33(6):510-5.
doi: 10.2337/diab.33.6.510.

Is somatostatin a true local inhibitory regulator of insulin secretion?

A Kanatsuka, H Makino, M Osegawa, J Kasanuki, T Suzuki, S Yoshida, H Horie

Is somatostatin a true local inhibitory regulator of insulin secretion?

A Kanatsuka et al. Diabetes. 1984 Jun.

Abstract

Pancreatic somatostatin was depleted after oral administration of cysteamine to rats, yet the B-cells in the isolated islets were morphologically and functionally intact. Compared with islets from the rats not given cysteamine, the somatostatin-depleted islets released larger amounts of insulin during 1 h of incubation by glucose or 3-isobutyl-1-methylxanthine stimulation. Therefore, the possibility that pancreatic somatostatin may locally regulate the inhibitory effects of insulin secretion has to be considered.

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