A private strain-specific idiotype-like structure discovered on CBA-anti-C57BL/6 T lymphocytes

Abstract

Using rabbit anti-CBA-anti-C57BL/6 sera, a private strain-specific idiotype-like determinant(s) was detected by cellular radioimmunoassay on activated CBA-anti-C57BL/6 T cells. This structure was not expressed on other activated T lymphocytes: CBA-anti-BALB/c; C3H-anti-C57BL/6; AKR-anti-C57BL/6; A/Sn-anti-C57BL/6; BALB/c- anti-C57BL/6; DBA/2-anti-C57BL/6. It is suggested that the gene(s) coding for the private strain-specific idiotype-like determinant(s) of T-cell antigen-recognizing receptors is not located within the murine H-2 complex.