[A study of cefoperazone prostatic tissue levels: difference between the gland and capsule]

Abstract

Prostatic tissue levels of Cefoperazone (CPZ) were determined in 34 patients with prostatic hypertrophy after the intravenous administration of 1 g of CPZ. Prostatic tissue levels of CPZ decreased slowly with time and the elimination half-life was 125 to 171 minutes. The CPZ concentration in the surgical capsule was higher than that in the gland. As compared with the minimal inhibitory concentrations of CPZ, the prostatic tissue levels were considered high enough for the treatment of post-prostatectomy and bacterial prostatitis. Neither the pathological type of prostatic hypertrophy, that of infiltrations, nor the weight of the removed tissue was correlated to the tissue levels of CPZ.