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. 1982;1(7):869-74.
doi: 10.1002/j.1460-2075.1982.tb01262.x.

Antibodies against a preselected peptide recognize and neutralize foot and mouth disease virus

E Pfaff, M Mussgay, H O Böhm, G E Schulz, H Schaller

Antibodies against a preselected peptide recognize and neutralize foot and mouth disease virus

E Pfaff et al. EMBO J. 1982.

Abstract

A major antibody combining site on foot and mouth disease virus (FMDV) serotype O1K has been identified in a predicted surface helix of viral protein 1 (VP1) between amino acid residues 144 and 159. A hexadecapeptide covering this sequence elicits high titers of antibodies that specifically recognize and neutralize FMDV. The high quality of the immune response is attributed to a particularly stable conformation of the antigenic amino acid sequence, which is most likely an alpha-helix.

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