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. 1984 Jun;65(3):377-88.

Pluripotential nature of mesotheliomata induced by inhalation of erionite in rats

N F Johnson, R E Edwards, D E Munday, N Rowe, J C Wagner

Pluripotential nature of mesotheliomata induced by inhalation of erionite in rats

N F Johnson et al. Br J Exp Pathol. 1984 Jun.

Abstract

Mesotheliomata can be induced more rapidly and more frequently by inhalation of erionite than by asbestos inhalation. Erionite-induced tumours have in general a similar ultrastructural appearance to inoculum-induced pleural and peritoneal mesotheliomata. Unusual features of these tumours were the presence of dense-cored vesicles and cells staining positively for neuron-specific enolase which indicated the presence of endocrine cells. In addition, one tumour showed differentiation towards bone-forming cells. The expression of both epithelial and mesodermal characteristics demonstrates the pluripotential nature of mesothelial cells under certain circumstances.

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