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. 1978 Feb;23(2):228-32.
doi: 10.1002/cpt1978232228.

Optimal phenytoin therapy: a new technique for individualizing dosage

P W Mullen

Optimal phenytoin therapy: a new technique for individualizing dosage

P W Mullen. Clin Pharmacol Ther. 1978 Feb.

Abstract

A simple, new technique (the direct linear plot) for predicting steady-state serum phenytoin concentrations is described. Although no calculations are required, reliable estimates (comparable with those derived by computer) of the Michaelis-Menten parameters can be readily determined and used graphically to predict the individualized dose required to achieve a desired serum concentration.

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