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. 1984 Oct;13(2):159-66.
doi: 10.1016/0165-4608(84)90057-8.

Correlation of differentiation state and silver staining of nucleolar organizers in the promyelocytic leukemia cell line HL-60

B R Reeves, G Casey, J R Honeycombe, S Smith

Correlation of differentiation state and silver staining of nucleolar organizers in the promyelocytic leukemia cell line HL-60

B R Reeves et al. Cancer Genet Cytogenet. 1984 Oct.

Abstract

We have applied nucleolar organizer region (NOR) silver staining to the promyelocytic leukemia cell line HL-60, before and after dimethylsulfoxide (DMSO) mediated differentiation. The results demonstrated a gradual suppression of rDNA transcription during terminal maturation of these bone-marrow-derived cells and support our hypothesis that there are characteristic NOR staining profiles for different bone marrow cell types.

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