Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1984 Oct;46(1):267-9.
doi: 10.1128/iai.46.1.267-269.1984.

Unique and common protective epitopes among different serotypes of group A streptococcal M proteins defined with hybridoma antibodies

J B Dale, E H Beachey

Unique and common protective epitopes among different serotypes of group A streptococcal M proteins defined with hybridoma antibodies

J B Dale et al. Infect Immun. 1984 Oct.

Abstract

A set of four monoclonal antibodies was produced against a highly purified pepsin extract of type 5 streptococcal M protein. Three of the four antibodies cross-reacted with purified M proteins from heterologous serotypes and opsonized the respective heterologous organisms. Our studies suggest that monoclonal antibodies may be useful in identifying subpeptides of various M proteins containing common, protective epitopes that are capable of evoking antibodies that would protect against several different potentially "rheumatogenic" serotypes.

PubMed Disclaimer

References

    1. J Exp Med. 1982 Oct 1;156(4):1165-76 - PubMed
    1. Proc Natl Acad Sci U S A. 1984 Apr;81(7):2203-7 - PubMed
    1. J Exp Med. 1939 Feb 28;69(3):425-45 - PubMed
    1. J Biol Chem. 1983 Nov 10;258(21):13250-7 - PubMed
    1. J Exp Med. 1978 Jun 1;147(6):1771-8 - PubMed

Publication types

MeSH terms

LinkOut - more resources