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Review
. 1984 Sep;3(3):361-4.
doi: 10.1007/BF02032343.

Interferon triggers experimental synovitis and may potentiate auto-immune disease in humans

T O Rosenbach, S Moshonov, U Zor, M Yaron
Review

Interferon triggers experimental synovitis and may potentiate auto-immune disease in humans

T O Rosenbach et al. Clin Rheumatol. 1984 Sep.

Abstract

From these data it appears that IFN is capable of stimulating prostaglandin E and hyaluronic acid production by human synovial fibroblasts in vitro and of initiating an inflammatory reaction in animal joints. In chronic arthritis its production may result from persisting viral or other antigenic stimulation. IFN may enhance the immune response and mediate the inflammatory process in the joint. Its role in the pathogenesis of rheumatic and various other autoimmune diseases is undergoing further study.

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