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. 1984 Oct 15;40(10):1151-2.
doi: 10.1007/BF01971468.

Stimulation of histamine synthesis in rat mast cells by compound 48/80 in vitro

A M Rothschild, I C Fortunato

Stimulation of histamine synthesis in rat mast cells by compound 48/80 in vitro

A M Rothschild et al. Experientia. .

Abstract

The histamine content of rat peritoneal fluid cells is doubled within 20 min by 0.5 microgram/ml of compound 48/80. Histamine catabolism inhibitors do not reproduce this effect; cells pre-incubated with alpha-fluoromethylhistidine are unresponsive to compound 48/80 which therefore activates pre-formed histidine decarboxylase rather than 'inducing' it. Non-mast cells showed no change after treatment with compound 48/80.

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