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. 1984 Nov;121(2):449-51.
doi: 10.1002/jcp.1041210226.

Detection of intranuclear clusters of Sm antigens with monoclonal anti-Sm antibodies by immunoelectron microscopy

G L Eliceiri, J S Ryerse

Detection of intranuclear clusters of Sm antigens with monoclonal anti-Sm antibodies by immunoelectron microscopy

G L Eliceiri et al. J Cell Physiol. 1984 Nov.

Abstract

It has been shown that small nuclear RNA (snRNA) species U1, U2, U4, U5, and U6 are found in the nucleus in the form of small nuclear ribonucleoprotein particles (snRNPs), and that anti-Sm antibodies react with snRNP polypeptides, which are associated with all five snRNAs. We report here a novel intranuclear complex, denoted "Sm cluster," detected by immunostaining with monoclonal anti-Sm antibodies in HeLa cells.

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