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. 1978 Feb;74(2 Pt 2):276-9.

Effect of one-month treatment with cimetidine on gastric secretion and serum gastrin and pepsinogen levels

K F Sewing, L Hagie, A F Ippoliti, J I Isenberg, I M Samloff, R A Sturdevant
  • PMID: 620908

Effect of one-month treatment with cimetidine on gastric secretion and serum gastrin and pepsinogen levels

K F Sewing et al. Gastroenterology. 1978 Feb.

Abstract

The inhibitory effects of cimetidine on gastric acid and pepsin secretion were studied before and after 1 month of treatment with 300 mg of cimetidine four times a day in 15 male duodenal ulcer patients. Cimetidine inhibited both pentagastrin- and peptone meal-stimulated acid secretion significantly better before, than after, 1 month of treatment. Similarly cimetidine inhibited pentagastrin-stimulated pepsin secretion significantly better before treatment. Meal-stimulated serum gastrin concentrations were significantly higher after treatment. The mechanism(s) of these effects was not apparent.

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