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. 1984 Nov;312(5990):127-34.
doi: 10.1038/312127a0.

The reactivity of anti-peptide antibodies is a function of the atomic mobility of sites in a protein

J A Tainer, E D Getzoff, H Alexander, R A Houghten, A J Olson, R A Lerner, W A Hendrickson

The reactivity of anti-peptide antibodies is a function of the atomic mobility of sites in a protein

J A Tainer et al. Nature. 1984 Nov.

Abstract

To study the nature of antigenic recognition, antibodies have been prepared against a set of peptide sequences representing both highly mobile and well-ordered regions of myohaemerythrin, based on X-ray crystallographic temperature factors. Anti-peptide antibodies against highly mobile regions react strongly with the native protein; anti-peptide antibodies from well-ordered regions do not. Mobility is a major factor in the recognition of the native protein by anti-peptide antibodies; this may be of general significance in protein-protein interactions.

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