Review
The chimpanzee as a model to test the side effects of human interferons
- PMID: 6210368
Item in Clipboard
Review
The chimpanzee as a model to test the side effects of human interferons
J Med Primatol.
1984.
Abstract
Interferon are naturally occurring proteins that are currently under evaluation as potential antiviral and antitumor agents. Currently all human interferons can in principle be produced in adequate amounts by recombinant DNA technology. Human interferons produce side effects, but because they are species-specific the toxicity cannot be tested in lower mammals. The chimpanzee is the only species in which the side effects of human interferon can be reproduced, and only in this species the toxicity of human interferons can be screened.
Similar articles
-
The use of interferon in viral hepatitis B.Tex Rep Biol Med. 1977;35:516-22. Tex Rep Biol Med. 1977. PMID: 358473 Review. No abstract available.
-
The interferon system as a basis for antiviral therapy or prophylaxis.Verh K Acad Geneeskd Belg. 1986;48(3):187-220. Verh K Acad Geneeskd Belg. 1986. PMID: 2430375 Review. No abstract available.
-
The chimpanzee-specific pericentric inversions that distinguish humans and chimpanzees have identical breakpoints in Pan troglodytes and Pan paniscus.Genomics. 2006 Jan;87(1):39-45. doi: 10.1016/j.ygeno.2005.09.003. Genomics. 2006. PMID: 16321504
-
[Interferons--its method of administration and adverse effect related to pharmacokinetics ].Gan To Kagaku Ryoho. 1984 Feb;11(2):186-93. Gan To Kagaku Ryoho. 1984. PMID: 6582804 Japanese.
-
Neuropsychiatric complications of interferons: classification, neurochemical bases, and management.Ann Clin Psychiatry. 2007 Apr-Jun;19(2):113-23. doi: 10.1080/10401230701333038. Ann Clin Psychiatry. 2007. PMID: 17612851 Review.
Cited by
-
Safety evaluation of biotechnology products.Drug Saf. 1990;5 Suppl 1:58-64. doi: 10.2165/00002018-199000051-00009. Drug Saf. 1990. PMID: 2182064 Review.
-
Preclinical safety testing of species-specific proteins produced with recombinant DNA-techniques. An attempt to transfer current experience into future testing strategies.Arch Toxicol. 1986 Dec;59(4):195-200. doi: 10.1007/BF00290537. Arch Toxicol. 1986. PMID: 3548648 Review.