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. 1982 Jan 1;201(1):95-9.
doi: 10.1042/bj2010095.

Presence of an atypical thermolabile species of beta-hexosaminidase B in metastatic-tumour tissue of human liver

J A Alhadeff, R T Holzinger

Presence of an atypical thermolabile species of beta-hexosaminidase B in metastatic-tumour tissue of human liver

J A Alhadeff et al. Biochem J. .

Abstract

An atypical thermolabile species of Hex B (hexosaminidase B) has been found in metastatic-tumour sites of human liver which has a thermostability curve similar to that of Hex A (hexosaminidase A), which is present in decreased amounts relative to the Hex A isoenzyme, and which exhibits decreased relative activity at acidic pH values (2.6-3.6) when compared with control-liver Hex B. This atypical Hex B isoenzyme has a normal apparent Michaelis constant (0.6 mM) for 4-methylumbelliferyl 2-deoxy-2-acetamido-beta-D-glucopyranoside. The presence of this atypical Hex B suggests that variant beta-chains are being produced in metastatic-tumour tissue.

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