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. 1976 Oct 23;2(7991):872-3.
doi: 10.1016/s0140-6736(76)90537-7.

80% of patients with intrinsic asthma are homozygous for HLA W6. Is intrinsic asthma a recessive disease?

J Brostoff, J F Mowbray, A Kapoor, S J Hollowell, M Rudolf, K B Saunders

80% of patients with intrinsic asthma are homozygous for HLA W6. Is intrinsic asthma a recessive disease?

J Brostoff et al. Lancet. .

Abstract

Of 26 patients with intrinsic asthma, 21 (81%) were homozygous for the histocompatibility antigen HLA-W6. Also, half the patients had complement defects, in particular low levels of C2. This is the first indication of a strong genetic component in intrinsic asthma, apart from that already known from family studies. These findings suggest that intrinsic asthma may be a recessive disease.

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