Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1982 Sep 1;60(17):978-82.
doi: 10.1007/BF01716958.

Pharmacological characterisation of cardiovascular histamine receptors in man in vivo

M J Boyce

Pharmacological characterisation of cardiovascular histamine receptors in man in vivo

M J Boyce. Klin Wochenschr. .

Abstract

Data from pharmacological studies carried out in healthy subjects using systemic histamine or impromidine and their antagonists are reviewed. Exogenous histamine by rapid injection appears to stimulate only H1-receptors. Chlorpheniramine alone antagonised the responses to histamine. The effects of cardiovascular H2-receptor stimulation are demonstrated best by a sustained and large dose of histamine given by infusion. If it be considered desirable to antagonise all the cardiovascular responses to endogenous histamine, the available pharmacological data in man suggest this would be achieved best by a combination of an H1-and H2-receptor antagonist.

PubMed Disclaimer

References

    1. Life Sci. 1980 Jun 30;26(26):2245-9 - PubMed
    1. Br J Pharmacol Chemother. 1954 Dec;9(4):413-8 - PubMed
    1. Agents Actions. 1979 Apr;9(1):29-30 - PubMed
    1. J Pharm Pharmacol. 1980 Feb;32(2):145-6 - PubMed
    1. J Pharm Pharmacol. 1981 Apr;33(4):246-7 - PubMed

MeSH terms