[Protective effect of Pseudomonas-specific immunoglobulin from the rabbit and of active immunization in experimental Pseudomonas sepsis in mice]

Abstract

Using the model of an experimental Pseudomonas septicemia in mice, the protective effect of specific antipseudomonal immunoglobulin from rabbits was examined. During bacterial spreading in the bloodstream, a protective effect could be demonstrated under certain conditions. The degree of protection was equivalent to that achieved by active immunization. After bacterial colonization and replication in parenchymal organs no further therapeutic effect could be detected.