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. 1982 Oct;79(20):6318-21.
doi: 10.1073/pnas.79.20.6318.

Distance from cohesive end site cos determines the replication requirement for recombination in phage lambda

F W Stahl, I Kobayashi, M M Stahl

Distance from cohesive end site cos determines the replication requirement for recombination in phage lambda

F W Stahl et al. Proc Natl Acad Sci U S A. 1982 Oct.

Abstract

Previous work showed that crossing-over in the middle of the chromosome of phage lambda requires more DNA replication than does crossing-over near the termini. Relocation of cos, the sequence that determines the lambda termini, alters the requirements for replication in a given marked interval, demonstrating that distance from cos determines the amount of DNA replication that is required for genetic exchange. This result supports a break and copy mechanism for recombination mediated by the red system of phage lambda.

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