Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1982;62(4):316-20.
doi: 10.1007/BF00304546.

Trisomy 21: origin of non-disjunction

J del Mazo, A Pérez Castillo, J A Abrisqueta

Trisomy 21: origin of non-disjunction

J del Mazo et al. Hum Genet. 1982.

Abstract

The Q-band heteromorphisms of chromosome 21 were used in a sample of 48 families with a Down's syndrome child to evaluate the origin of non-disjunction. The parental origin and the meiotic error were determined in 27 families, and in eight families only partial information was obtained. Paternal and maternal origin of non-disjunction was in a 1:3 ratio. Failures were five times more frequent in first than in second meiotic division in both sexes. The mean parental age and environmental factors in relation to the origin of the anomaly are discussed. Our results are compared with those obtained previously in similar studies by other authors.

PubMed Disclaimer

References

    1. Hum Genet. 1978 Feb 16;40(3):259-68 - PubMed
    1. Hum Genet. 1979 Feb 15;46(3):285-94 - PubMed
    1. Hum Hered. 1977;27(1):59-72 - PubMed
    1. Ann Hum Genet. 1977 Jan;40(3):299-306 - PubMed
    1. Hereditas. 1972;70(1):153-4 - PubMed

Publication types

LinkOut - more resources