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. 1983 Feb 11;272(2):359-65.
doi: 10.1016/s0378-4347(00)86139-3.

High-performance liquid chromatography of pefloxacin and its main active metabolites in biological fluids

G Montay, Y Blain, F Roquet, A Le Hir

High-performance liquid chromatography of pefloxacin and its main active metabolites in biological fluids

G Montay et al. J Chromatogr. .

Abstract

We describe a high-performance liquid chromatographic (HPLC) method for the analysis of pefloxacin, a new antibacterial agent, in plasma and urine following administration of a therapeutic dose in humans. HPLC assay of pefloxacin and its two main active metabolites in urine is also described. The applicability of the methods to pharmacokinetic studies of pefloxacin in humans is demonstrated.

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