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. 1983 Apr;130(4):1592-5.

The ontogeny of antigen-presenting cells in fetal thymus evaluated by MLR stimulation

J H Robinson
  • PMID: 6220060

The ontogeny of antigen-presenting cells in fetal thymus evaluated by MLR stimulation

J H Robinson. J Immunol. 1983 Apr.

Abstract

This study demonstrates that cells with the characteristics of antigen-presenting cells (APC) are present in murine thymus from as early as 14 days gestation, around the time that T lymphopoiesis is initiated in the embryo. Thymic APC were identified as la+ adherent cells capable of presenting alloantigens to T cells in MLC. The possible role of these cells in thymocyte differentiation is discussed.

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